Per- and polyfluoroalkyl substances (PFAS)

Standard Operating Procedures (SOP) Requirement

If you are using PFAS in powdered form, you must submit a Standard Operating Procedure (SOP) to EHS for review and approval prior to beginning any work.  Aqueous solutions should be used wherever possible.

Powdered PFAS presents an inhalation risk that requires specific handling procedures to minimize exposure and environmental contamination. The SOP must include details on containment, personal protective equipment (PPE), decontamination procedures, and waste disposal. SOP review should be added to Site-Specific Training requirements.

Fillable SOP templates are available on the EHS website.

Prior Approval for Animal Studies Requirement

Use of PFAS in animals must have prior approval from EHS and the IACUC.  PFAS can bioaccumulate and pose health risks to animals and potentially to personnel handling these animals. Prior approval ensures that all safety and ethical considerations are addressed.

General PFAS Handling Guidelines

Good lab hygiene, technique, and housekeeping is imperative to using PFAS safely. Ensure that the following practices are followed:

  • Personal Protective Equipment (PPE): All personnel must wear standard laboratory attire: nitrile gloves, lab coat, and eye protection, long pants, and closed-toe shoes when handling PFAS.
  • Aqueous Phase: Use PFAS chemicals in aqueous form if possible to reduce the possibility of inhalation. For work with powdered forms, respiratory protection may be required. Must be approved and fit tested by EHS prior to use.
  • Containment: All work with PFAS must be conducted in a fume hood or other approved containment system to prevent environmental contamination and personal exposure.
  • Waste Disposal: PFAS waste, including contaminated PPE, must be collected in designated containers and disposed of according to EHS hazardous waste protocols.
  • Spill Response: In the event of a PFAS spill, immediately follow spill response procedures as outlined in your lab’s chemical hygiene plan. Report any significant spills to EHS without delay.

Chemical Hygiene